作者: sarah

康哲药业:芦可替尼乳膏(白癜风)大湾区首批处方落地

深圳, 2024年10月18日 - (亚太商讯 via SeaPRwire.com) - 康哲药业控股有限公司("康哲药业")欣然宣布,磷酸芦可替尼乳膏("芦可替尼乳膏"或"产品")在中山陈星海中西医结合医院、佛山复星禅诚医院、以及东莞松山湖东华医院为符合条件的白癜风患者开出大湾区首批处方。产品于2024年4月11日获得澳门政府药物监督管理局(ISAF)批准新药上市申请,随后通过"港澳药械通"政策,并于8月19日获得广东省药品监督管理局批准,正式落地粤港澳大湾区内地指定医疗机构,用于12岁及以上青少年和成人患者伴面部受累的非节段型白癜风的治疗,为相关适应症患者提供了全新治疗选择。此外,芦可替尼乳膏白癜风适应症新药上市许可申请已于9月24日获得中国国家药品监督管理局(NMPA)受理。根据海南博鳌乐城国际医疗旅游先行区药品真实世界数据应用试点程序有关规定,芦可替尼乳膏在中国开展真实世界研究,疗效积极,与境外关键临床研究结果一致。所有的次要疗效指标均显示出与主要疗效指标一致的获益趋势,且治疗时间越长,患者的白癜风治疗效果持续改善。同时利用了乐城先行区安全监测数据,未发现新的安全性事件。不良反应的严重程度大部分均为1级或2级,未发生导致停药或退出的不良事件(AE),未发生研究药物相关的严重不良事件(SAE)。若产品于中国大陆获批上市,其有望成为首个经NMPA批准用于白癜风复色的处方药,将为中国广大白癜风患者带来治疗新曙光。除上述进展外,产品此前于2023年8月12日获得海南省药监局批准临床急需进口,并于8月18日正式落地海南博鳌乐城国际医疗旅游先行区,用于12岁及以上青少年和成人患者伴面部受累的非节段型白癜风的局部治疗。受益于国家赋予海南自由贸易港、博鳌乐城国际医疗旅游先行区"先行先试"特许政策,中国白癜风患者可在博鳌超级医院先行申请使用产品并接受专家团队的治疗。截至2024年6月30日,已有超3,200例患者在博鳌超级医院使用芦可替尼乳膏进行治疗。康哲药业始终以患者为中心,以临床需求驱动创新,为提升药物可及性而持续努力。本次芦可替尼乳膏得益于"港澳药械通"政策支持,先行获批引入大湾区,并完成首批处方落地,缩短了中国白癜风患者使用创新药的用药时差,让更多国内白癜风患者获益。展望未来,康哲药业将继续为满足中国患者未尽之需而奋进,持续挖掘国际品质的新药、好药,高效推动产品临床开发和商业化发展,以差异化的创新突破为病患带来更多优质的医药产品,为守护患者健康生活和生命质量贡献力量。关于芦可替尼乳膏芦可替尼乳膏(Opzelura),为Incyte的JAK1/JAK2选择性抑制剂芦可替尼的创新乳膏制剂,已获得美国食品和药物管理局(FDA)批准用于12岁及以上非节段型白癜风患者的局部治疗。截至目前,芦可替尼乳膏是首个也是唯一一种在美国获批使用的白癜风复色产品[1]。此外,产品在美国获批用于传统外用处方疗法不可取或不能充分控制病情之12岁及以上非免疫功能低下的轻中度AD患者的局部短期和非持续性慢性治疗[2]。产品也于欧洲获批用于12岁及以上青少年及成人患者伴面部受累的非节段型白癜风的治疗[3]。康哲药业于2022年12月2日,通过其附属公司-康哲美丽与Incyte就用于治疗自身免疫性炎症皮肤病的芦可替尼乳膏制剂订立合作和许可协议("许可协议")。根据该等许可协议,康哲药业通过康哲美丽获得在中国大陆、香港特别行政区、澳门特别行政区、台湾地区及东南亚十一国(印尼、菲律宾、越南、泰国、缅甸、马来西亚、柬埔寨、老挝、新加坡、东帝汶以及文莱)("区域")开发、注册及商业化产品的独家许可权利,以及在区域内生产产品的非独家许可权利。许可协议期限开始于许可协议生效日,自产品在区域内首次商业化销售之日起拥有十年的授权期限("授权期限")。授权期限届满后,根据许可协议约定的特定条件,许可协议期限可延长十年("初始延展授权期限")。初始延展授权期限届满后,根据许可协议约定的特定条件,双方可另行协商许可协议的延长期限。Incyte拥有产品的全球开发和商业化权利,产品在美国及欧洲以Opzelura的名称销售。Opzelura及其logo为Incyte的注册商标。关于白癜风白癜风是一种慢性自身免疫性疾病,其特征是皮肤色素脱失,其发病原因为产生色素的细胞即黑素细胞的缺失。据估算,中国白癜风患者约1,400万[4]。白癜风患者中约85%为非节段型白癜风。外用皮质类固醇(TCS)及钙调神经磷酸酶抑制剂(CI)均为非节段型白癜风的标签外用药,然而,这些现有外用药物疗法有长期用药的不良反应或疗效有限的临床痛点[5、6]。关于康哲药业康哲药业是一家链接医药创新与商业化,把控产品全生命周期管理的开放式平台型企业,致力于提供有竞争力的产品和服务,满足尚未满足的医疗需求。康哲药业专注于全球首创(FIC)及同类最优(BIC)的创新产品,并高效推进创新产品临床研究开发和商业化进程,赋能科研成果向诊疗实践的持续转化,造福患者。康哲药业聚焦专科领域,拥有被验证的商业化能力,广泛的渠道覆盖和多疾病领域专家资源,核心在售产品已获领先的学术与市场地位。康哲药业围绕优势专科领域不断纵深发展,以巩固心脑血管/消化业务竞争力,并将皮肤医美、眼科业务独立运营,培育专科小领域的大龙头,提升专科规模效率。同时业务版图拓展至东南亚市场,着力成为全球药企进军东南亚市场的"桥头堡",助力康哲药业高质量持续健康发展。参考文献/资料:1.FDA批准信息可在FDA官网查询,网址:https://www.fda.gov/drugs/news-events-human-drugs/fda-approves-topical-treatment-addressing-repigmentation-vitiligo-patients-aged-12-and-older2.FDA批准信息可在incyte官网查询,网址:https://investor.incyte.com/news-releases/news-release-details/incyte-announces-us-fda-approval-opzeluratm-ruxolitinib-cream3.EMA批准信息可在EMA官网查询,网址:https://www.ema.europa.eu/en/medicines/human/EPAR/opzelura4.Ezzedine K, Eleftheriadou V, Whitton M, van Geel N. Vitiligo. Lancet. 2015;386(9988):74-84. doi:10.1016/S0140-6736(14)60763-75.《白癜风诊疗共识(2021版)》6.Kubelis-Lopez DE,Zapata-Salazar NA,Said-Fernandez SL, Sanchez-Dominguez CN,Salinas-Santander MA,Martinez-Rodriguez HG,Vazquez-Martinez OT,Wollina U,Lotti T,Ocampo-Candiani J. Updates and new medical treatments for vitiligo (Review). Exp Ther Med. 2021 Aug;22(2):797. doi: 10.3892/etm.2021.10229. Epub 2021 May 25. PMID: 34093753; PMCID: PMC8170669.康哲药业免责与前瞻性声明本新闻无意向您做任何产品的推广,非广告用途。本新闻不对任何药品和医疗器械和/或适应症作推荐。若您想了解具体疾病诊疗信息,请遵从医生或其他医疗卫生专业人士的意见或指导。医疗卫生专业人士作出的任何与治疗有关的决定应根据患者的具体情况并遵照药品说明书。由康哲药业编制的此新闻不构成购买或认购任何证券的任何要约或邀请,不形成任何合约或任何其他约束性承诺的依据或加以依赖。本新闻由康哲药业根据其认为可靠之资料及数据编制,但康哲药业并无进行任何说明或保证、明述或暗示,或其他表述,对本新闻内容的真实性、准确性、完整性、公平性及合理性不应加以依赖。本新闻中讨论的若干事宜可能包含涉及康哲药业的市场机会及业务前景的陈述,该等陈述分别或统称为前瞻性声明。该等前瞻性声明并非对未来表现的保证,存在已知及未知的风险、不明朗性及难以预知的假设。康哲药业并不采纳本新闻包含的第三方所做的任何前瞻性声明及预测,康哲药业对该等第三方声明及预测不承担责任。 Copyright 2024 亚太商讯 via SeaPRwire.com.

18 10 月, 2024

MHI Thermal Systems Receives Order for Large-scale Centrifugal Chillers from Empower for its District Cooling Plants in Dubai, UAE

TOKYO, Oct 18, 2024 - (JCN Newswire via SeaPRwire.com) - Mitsubishi Heavy Industries Thermal Systems, Ltd. (MHI Thermal Systems), a part of Mitsubishi Heavy Industries (MHI) Group, has signed a new agreement with Emirates Central Cooling Systems Corporation PJSC (Empower), the world's largest district cooling services provider(Note1), to supply large-scale centrifugal chillers to Empower's District Cooling plants in Dubai, UAE.CEO H.E. Ahmad Bin Shafar and President Ito at the Signing CeremonyUnder the agreement, MHI Thermal Systems will supply 18 advanced chillers that will be ready for delivery from the beginning of 2025 for an aggregate cooling capacity of 56,250 refrigeration tons (RT) (Note2). They will be used in three District Cooling System (DCS) plants that Empower operates and will supply chilled water for cooling to residential, commercial, healthcare, educational, and multi-use projects. The agreement also includes a provision allowing Empower to increase the order up to 31 December 2024, potentially increasing the total capacity to 100,000 RT.MHI Thermal Systems has previously received an order for large-scale centrifugal chillers from Empower in 2021. The latest contract was received in recognition of the excellent chilling efficiency and environmental performance of MHI Thermal Systems chillers, as well as the operational performance and after-sales service from the previous order. Delivery is scheduled to begin sequentially from 2025, bringing the total number of chillers delivered to Empower to at least 46 units. The use of DCS is part of the Dubai government's long-term strategies, aiming to achieve savings of at least 30% by 2030 and 50% by 2050 in electricity, water and transport fuel consumption.MHI Thermal Systems and Empower held a contract signing ceremony in Dubai on October 8, attended by Empower CEO H.E. Ahmad Bin Shafar, and MHI Thermal Systems President Yoshihiro Ito.President Ito said: "We are proud that Empower has highly evaluated the performance and the quality of the after-sales service of the units previously delivered, and has once more chosen MHI Thermal Systems' chillers for these latest projects. We will continue improving energy efficiency while continuously enhancing operational and production effectiveness. We will continue implementing our advanced solutions to Empower's DCS plants so that our partnership will also contribute to the Dubai and the UAE's carbon emissions reduction strategy."Ahmad Bin Shafar emphasized that this deal offers both parties a significant opportunity to advance the district cooling sector and accelerate efforts toward a carbon-free future through energy-efficient solutions. He noted that these solutions reduce environmental impact and pave the way for a more sustainable tomorrow. Bin Shafar also highlighted that the agreement supports Empower's goal of upgrading its plants with innovative technologies that promote efficient, energy-saving production processes, aligning with the company's environmental and societal objectives and its commitment to safeguarding resources for future generations.Empower is responsible for more than 80% of Dubai's district cooling capacity, supplying chilled water for cooling from 87 district cooling plants, making it the world's largest district cooling services provider.MHI Thermal Systems, as a part of MHI Group, will continue to respond to customer needs and contribute to the realization of a carbon-neutral world through the supply of energy-efficient centrifugal chillers.(1) In terms of connected capacity(2) 1 refrigeration ton = approx. 3.516 kWAbout MHI GroupMitsubishi Heavy Industries (MHI) Group is one of the world’s leading industrial groups, spanning energy, smart infrastructure, industrial machinery, aerospace and defense. MHI Group combines cutting-edge technology with deep experience to deliver innovative, integrated solutions that help to realize a carbon neutral world, improve the quality of life and ensure a safer world. For more information, please visit www.mhi.com or follow our insights and stories on spectra.mhi.com. Copyright 2024 JCN Newswire via SeaPRwire.com.

18 10 月, 2024

Fujitsu and Teikyo University begin joint research on UX platform for promotion of lifestyle improvement using XR, spatial computing, and generative AI

TOKYO, Oct 18, 2024 - (JCN Newswire via SeaPRwire.com) - Fujitsu and the Okinaga Research Institute at Teikyo University announced that, as of today, they will begin a full-scale joint research project for the development of a user experience (UX) platform. This platform will help to improve health consciousness and healthcare literacy by increasing patients’ understanding of their internal condition through the use of digital technology, such as extended reality (XR) and spatial computing (1).In this research project, Fujitsu and the Okinaga Research Institute will use XR and spatial computing to recreate a patient's internal anatomy in a virtual space, enhancing their understanding of the locations where health issues may arise. The two parties will examine how this visualization can foster health consciousness, behavioral change, and improved patient outcomes. The technology will be used in interviews with patients who have been advised to improve their lifestyle based on health check results. In addition, the two parties will also create an AI healthcare supporter avatar with generative AI technology to follow up with patients and will examine its effect on improving patient healthcare literacy.BackgroundIn recent years, lifestyle-related diseases have increased among both the elderly and younger populations. Preventing serious illness through lifestyle improvements is expected to reduce the national healthcare burden, improve corporate labor productivity, and enhance individual quality of life. Consequently, the Japanese Ministry of Health, Labour and Welfare requires health insurance societies to devise and implement data health plans. From this, effective improvements are being promoted through the plan-do-check-act (PDCA) cycle. In this cycle, data from the results of health checkups retained by health insurance societies and medical treatment bills are used to analyze the relationship between the data obtained from the medical examination and diseases to improve patient’s lifestyle.Improving lifestyles requires not only the support of healthcare providers but also a fundamental shift in individual mindset.In October 2022, Fujitsu and the Okinaga Research Institute started conducting research to eliminate the communication gap between doctors and patients by using XR, spatial computing, and generative AI in informed consent. This research led to the development such as virtual internal body models generated from patients’ biological data and technology for an AI medical supporter avatar. This research forms the basis of this latest project.Roles of Both Parties:1. Fujitsu- Conducting design research (2) with related parties and experts to identify hinderances to people’s awareness of true lifestyle improvement- Creating UX/UI scenarios for people to autonomously improve their lifestyles- Providing development support for an initial prototype, suggest improvements, and conduct a demonstration test with the prototype2. Okinaga Research Institute:- Providing medical expertise- Sharing visualization expertise in the area of medicine- Developing an initial prototype that uses organ dataFuture PlansBased on the results of this joint research project, Fujitsu and Teikyo University will contribute to improving people’s well-being and solving societal issues related to health by preventing lifestyle-related diseases through the societal implementation of health guidance that utilizes digital technology.(1) Spatial computing: A technology that seamlessly integrates physical and digital spaces, enabling people to interactively control information within that space.(2) Design research: Research with the aim of designing products and services from the user’s point of view. In this research, various information is collected and organized to identify potential customer needs and discover new issues and value.About FujitsuFujitsu’s purpose is to make the world more sustainable by building trust in society through innovation. As the digital transformation partner of choice for customers in over 100 countries, our 124,000 employees work to resolve some of the greatest challenges facing humanity. Our range of services and solutions draw on five key technologies: Computing, Networks, AI, Data & Security, and Converging Technologies, which we bring together to deliver sustainability transformation. Fujitsu Limited (TSE:6702) reported consolidated revenues of 3.7 trillion yen (US$26 billion) for the fiscal year ended March 31, 2024 and remains the top digital services company in Japan by market share. Find out more: www.fujitsu.com.Press Contacts:Fujitsu LimitedPublic and Investor Relations DivisionInquiriesTeikyo UniversityHeadquarters Public Relations SectionInquiries Copyright 2024 JCN Newswire via SeaPRwire.com.

18 10 月, 2024

TANAKA to Provide Medals Representing the Event Concept with a Design of Gently Curved Circular Expansion for the Tokyo Legacy Half Marathon 2024

TOKYO, Oct 18, 2024 - (JCN Newswire via SeaPRwire.com) - TANAKA Holdings Co., Ltd. (Head office: Chuo-ku Tokyo; Group CEO: Koichiro Tanaka) will provide and donate gold, silver, and bronze medals to the top three finishers in the half marathon (elite athletes) and elite para-athletes (wheelchair and visual impairment) award categories at the Tokyo Legacy Half Marathon 2024. The Tokyo Legacy Half Marathon 2024 is organized by the Tokyo Marathon Foundation and will be held on October 20, 2024.*If the top three finishers above have a guide runner, a medal will also be provided to the guide runner.Medals Using Gently Expanding Curves to Represent the Event’s ConceptThe medals were designed based on the concept of the Tokyo Legacy Half Marathon: "We want to expand the opportunity for everyone to run, including those who have never run before, and create an event in which anyone can participate." The front of the medal features the event title, Tokyo Legacy Half Marathon 2024, written in English, and incorporates the event logo, which uses a motif of gently curved circles expanding outward. This logo represents the Earth’s continuous rotation, honoring the dedication of the runners who have trained tirelessly for 365 days leading up to the event. Additionally, the design of the Earth is reduced to about half the size of the medal to symbolize the half marathon.On the back of the medal, Tokyo Legacy Half 2024 is inscribed in braille, along with the TANAKA Precious Metals logo, and the word "FINISHER" and the event date. The ribbon is designed with the event logo, which resembles a tapestry of interwoven lines representing each runner, volunteer, and spectator.About the Tokyo Legacy Half Marathon 2024The Tokyo Legacy Half Marathon 2024 is a public participation half marathon (21.0975 km) that is half the distance of the Tokyo Marathon (42.195 km). It was born from the desire to create a half marathon that would give the extraordinary experience of running to everyone. This year, the event’s tagline is "If it’s a half marathon, I can barely make it, Maybe." aiming to offer a race where a wide variety of runners can enjoy the streets of Tokyo at their own pace.(Official website of the event: https://legacyhalf.tokyo/en/ )Since the inaugural event in 2022, TANAKA Precious Metals has been producing the medals awarded at the Tokyo Legacy Half Marathon, and this will be their third time providing them. In addition to the Tokyo Legacy Half Marathon, the company has also produced winner’s medals for the Tokyo Marathon, supported the promotion of para-sports as an official partner of the Japanese Para-Sports Association (JPSA), and manufactured and sold the official commemorative medals for the 1964 Tokyo Olympics. TANAKA Precious Metals will continue to produce medals made of precious metals and support the promotion of sports with the aim of contributing to the realization of a prosperous society.Overview of the Tokyo Legacy Half Marathon 2024 MedalsWeight, size and materialGold Medal: approx. 55g; approx. 55mm in diameter and approx. 2.3mm thick; pure silver with gold platingSilver Medal: approx. 55g; approx. 55mm in diameter and approx. 2.3mm thick; pure silverBronze Medal: approx. 45g; approx. 55mm in diameter and approx. 2.3mm thick; pure copper Race Information of the Tokyo Legacy Half Marathon 2024OrganizerTokyo Marathon FoundationCo-organizersTokyo Metropolitan Government; JAAF (Japan Association of Athletics Federations); Tokyo Sports Association for the DisabledManaging OrganizationTokyo Athletics AssociationOperation SupportJapan Para AthleticsSupporting OrganizationsJapan Industrial Track & Field AssociationOfficial PartnersSky Co., Ltd.; Otsuka Pharmaceutical Co., Ltd.; New Balance Japan, Inc.; Tokyo Tatemono Co., Ltd.; KINTETSU INTERNATIONAL; Hisamitsu Pharmaceutical Co.,Inc.; Tokyo Kiraboshi Financial Group, Inc.; TANAKA Holdings Co., Ltd.; Rokko Butter, Co., Ltd.; Photocreate Co.,Ltd.; SEIKO GROUP CORPORATIONOfficial SuppliersNIHON KOHDEN CORPORATION; Porsche Japan K.K.DateSunday, October 20, 2024 (rain or shine)Start/Finish AreaJapan National Stadium (Kasumigaoka-machi, Shinjuku, Tokyo) About TANAKA Precious MetalsSince its foundation in 1885, TANAKA Precious Metals has built a portfolio of products to support a diversified range of business uses focused on precious metals. TANAKA is a leader in Japan regarding the volume of precious metals it handles. Over many years, TANAKA has manufactured and sold precious metal products for industry and provided precious metals in such forms as jewelry and assets. As precious metals specialists, all Group companies in Japan and worldwide collaborate on manufacturing, sales, and technology development to offer a full range of products and services. With 5,355 employees, the group’s consolidated net sales for the fiscal year ending December 2023, was 611.1 billion yen.TANAKA Holdings Websitehttps://www.tanaka.co.jp/english/Press inquiriesTANAKA Holdings Co., Ltd.https://tanaka-preciousmetals.com/en/inquiries-for-mediaPress Release: https://www.acnnewswire.com/docs/files/20241017.pdf  Copyright 2024 JCN Newswire via SeaPRwire.com.

18 10 月, 2024

达势股份-达美乐中国收益和利润双双增长 持续优化投资者结构

香港, 2024年10月18日 - (亚太商讯 via SeaPRwire.com) - 近期,政府推出了一系列刺激经济和提振消费信心的政策,推动股市反弹。消费股在第三季度表现出色,领涨市场。其中,达势股份-达美乐中国("达美乐中国"或"达势股份"或"公司")(1405.HK),作为达美乐比萨在中国大陆、中国香港特别行政区和中国澳门特别行政区的独家总特许经营商,进一步优化投资者结构,意在为股东创造长期丰厚回报。2024年第三季度,达势股份被纳入香港恒生综合指数成分股及沪港通、深港通,展现了其市场信誉和增长潜力,同时提升公司流动性。自2023年3月28日上市以来,截至2024年10月15日,公司股价已上涨逾60%,远超恒生综合指数的同期表现[1]。为了进一步优化投资者结构、增强交易流动性,近期达美乐比萨间接全资子公司Domino's Pizza LLC公布同意通过场外大手交易方式,将其持有的截至2024年10月17日的10,000,000股达美乐中国的股份,约占其已发行股本总额的7.66%,出售给其他机构投资者。此次股份出售之后,Domino's Pizza LLC仍保留达美乐中国已发行股本总额的6.21%,其剩余股份禁售期为90天。达美乐比萨将继续保持与达美乐中国之间稳固且持久的关系。本次交易将进一步提升达势股份的流动性,为其投资者结构注入新的活力。一些知名国际投资银行分析师对达势股份给出"买入"或"优于预期"评级,显示出对公司基本面和股票表现的信心。达势股份通过战略扩张、高效运营和高消费者满意度持续展现其强劲实力。公司的成功主要归功于其4D战略:高质量的门店开发(Development)、高质价比的美味比萨(Delicious Pizza at Value)、高效的外送体验(Delivery)和数字化能力(Digital)。这一全面的战略布局使公司能为不断增长的消费者群体稳定提供高质价比的比萨。自2021年至2023年,达势股份实现复合年均增长率(CAGR)37.6%。2024年上半年,收益高达人民币20.4亿元,报告净利润和经调整净利润(税后)首次实现双双转正。达势股份的"走深走广"战略在其增长中发挥了重要作用。截至2024年9月30日,达势股份在全国33个城市经营978家门店,今年已新开210家门店,展现出强劲的门店网络扩张势头。目前,净新增门店数、在建门店数及签约门店数总和已接近全年目标的100%。公司预计将在第四季度开设第1,000家门店,未来两年每年新增300至350家门店。强劲的业绩表现支持了达势股份门店网络扩张。截至2024年第三季度,在达美乐比萨全球超21,000家门店的首30日销售排行榜中,达美乐中国门店在榜单前30名中占据了28个席位。自2017年第三季度现任管理团队接任以来,达势股份已连续29个季度实现同店销售额增长(SSSG),无论行业如何表现,公司始终保持增长态势。同时,达势股份的全面数字化战略也起到了关键作用,增强了消费者黏性。截至9月,公司会员计划"达人荟"会员人数已突破2,170万。过去一年里,1,100万名新用户通过达美乐中国的官方网上订餐渠道[2]首次下单。展望未来,达势股份将继续推进扩张并优化运营,在中国这个潜力无限的比萨市场中,公司将通过持续不断的创新和优化,来实现稳健且可持续的利润增长。达势股份以其坚定不移的战略,已经建立起了一套坚实而有竞争力的运营体系,确保在日益激烈的竞争环境中保持行业领先地位。在未来的发展道路上,达势股份将进一步巩固其市场领导地位,通过不断提升产品质量、服务水平以及顾客体验,为消费者带来更多的价值。[1]以达势股份及香港恒生综合指数2023年3月28日及2024年10月15日收盘价为准。[2]官方网上订餐渠道:达美乐比萨中国官网/官方微信公众号及小程序/官方APP。 Copyright 2024 亚太商讯 via SeaPRwire.com.

18 10 月, 2024

A Joint Regional Cohort Study by Shimadzu, Eisai, Oita University, and Usuki City Medical Association

Shimadzu Corporation, Eisai Co., Ltd., Oita University, and Usuki City Medical Association have demonstrated the utility of blood biomarkers in predicting the accumulation of amyloid beta (Aβ)(1) in the brain, a noted cause of Alzheimer’s disease(2), in a cohort study conducted in Usuki City, Oita from November 2022. A research paper reporting the details of this study was published on October 10, 2024, in the journal Alzheimer’s & Dementia: Translational Research & Clinical Interventions.This joint research attempts to develop Japan’s first diagnostic workflow for mild cognitive impairment (MCI) due to Alzheimer’s disease and mild dementia based on blood biomarkers. Comprising a phase 1 and phase 2 study, the phase 1 study uses frozen samples of blood plasma from a regional cohort collected by a prospective cohort study performed in Usuki City between 2015 and 2019 to evaluate the utility of blood biomarkers in predicting Aβ accumulation in the brain. The phase 2 study is a prospective study that uses blood plasma samples collected from 100 newly recruited subjects through diagnostic workflows adopted at all levels of health care, from primary care physicians to specialists certified by dementia-related societies, to evaluate the psychological impact on participants of different results and who discloses them.The research paper primarily compiles results from the phase 1 study. The ability of blood biomarkers to predict the results of amyloid PET scans(3) was evaluated in terms of an area under the curve (AUC) value. Blood biomarker measurements performed by Shimadzu resulted in an AUC value of 0.94 and identified PET-positive patients in the regional cohort with a high degree of accuracy. The joint research also revealed the possibility to predict the progression of clinical symptoms using baseline blood biomarker results, i.e., the progression from MCI due to Alzheimer's disease to Alzheimer's dementia from analysis of participant data over a seven-year observation period. Blood biomarker testing is less invasive than amyloid PET and cerebrospinal fluid testing(4), and could reduce patient stress and help predict the future onset of dementia if used as an alternative to these two diagnostic methods. The data collection stage of phase 2 is complete with plans in place to carry out data analysis and draft an overall report of the results of both phases of the joint research.The four parties involved in this joint research are committed to building an ecosystem that improves the early diagnosis of Alzheimer’s through diagnostic workflows adopted at all levels of health care from primary care physicians to specialists who are members of dementia-related societies, and through this research develop social infrastructure that ensures patients and their families live happy and fulfilling lives.Comment by Noriyuki Kimura, an Associate Professor at the Department of Neurology, Faculty of Medicine, Oita UniversityTreatment of Alzheimer’s disease is approaching a new turning point with the emergence of anti-amyloid beta antibodies that will require the diagnosis of Alzheimer’s disease at the MCI or early dementia stage. Biomarker-based tests to detect amyloid accumulation in the brain include amyloid PET scans and cerebrospinal fluid testing, but PET scans are expensive and cerebrospinal fluid testing is highly invasive. Blood biomarker testing is low-cost and less invasive, and its adoption promises to reduce the financial and physical burden on patients.(1) Amyloid beta is a protein believed to cause Alzheimer’s disease that accumulates in the brain to form senile plaques beginning around 20 years before the onset of Alzheimer’s disease.(2) Alzheimer’s disease is the most common cause of dementia and its key pathological hallmarks are senile plaques, neurofibrillary tangles, and neuronal cell death.(3) Amyloid PET is a brain imaging test that can visualize amyloid beta accumulation in the brain.(4) Cerebrospinal fluid testing collects cerebrospinal fluid and tests it for amyloid-β 42, amyloid-β 40, phosphorylated tau protein, and total tau protein, which are biomarkers of Alzheimer’s disease.Research Paper InformationJournal name: Alzheimer's & Dementia: Translational Research & Clinical InterventionsTitle of paper: Plasma amyloid beta biomarkers predict amyloid positivity and longitudinal clinical progression in mild cognitive impairment.Authors: Takuya Ataka, Noriyuki Kimura, Naoki Kaneko, Teruaki Masuda, Yosuke Takeuchi, Kenichi Yabuuchi, Takeshi Mizukami, Tsukasa Takeuchi, Temmei Ito, Hideaki Tasai, Takehiko Miyagawa, Shunya Hanai, Shinichi Iwamoto, and Etsuro MatsubaraDOI: 10.1002/trc2.70008Related InformationNovember 22, 2022 Press releaseTo Develop Japan’s First Blood Biomarker-Based Diagnostic Workflow for DementiaShimadzu, Eisai, Oita University, and Usuki City Medical Association Commence Joint Researchwww.eisai.com/news/2022/news202280.html For Press and Media Inquiries, Please Contact:Shimadzu CorporationCorporate Communication Department Phone: +81-75-823-1110Eisai Co., Ltd.Public Relations Department Phone: +81-3-3817-5120Oita UniversityDepartment of Neurology, Faculty of Medicine Phone: +81-97-586-5814Usuki City Medical AssociationUsuki City Medical Association Office Phone: +81-972-63-0099 Copyright 2024 JCN Newswire via SeaPRwire.com.

17 10 月, 2024

国泰君安国际再次签署《好雇主约章》 营造和谐共融工作环境

香港, 2024年10月17日 - (亚太商讯 via SeaPRwire.com) - 国泰君安国际控股有限公司("国泰君安国际"、"公司"或"集团",股份代号:1788.HK)欣然宣布,公司连续第六年参与由香港劳工处推出的《好雇主约章》计划,致力于采取良好的人事管理措施,并为员工营造家庭友善的工作环境。《好雇主约章》2024以「为你『家』『友』好雇主」为主题,鼓励各行业及不同规模的雇主推行及优化以雇员为本的家庭友善雇佣措施,将心比己体谅雇员兼顾工作及家庭的责任,缔造家庭友善的工作环境。此次签署《好雇主约章》,展现了公司在员工关怀及营造和谐共融工作环境方面所做出的努力。国泰君安国际一直关爱员工,秉承「人才是第一资源」的经营理念,奉行「以人为本,协同协作」的人才理念,视员工为企业的核心资产,打造包容、健康的工作环境,并提供充足的资源支持员工的成长与发展。未来,国泰君安国际将继续致力于提升员工满意度,营造一个更加友善和谐的工作环境,为缔造和谐共融的社会贡献力量。 Copyright 2024 亚太商讯 via SeaPRwire.com.

17 10 月, 2024

Update on Regulatory Review of Lecanemab for Early Alzheimer’s Disease in Australia

TOKYO and CAMBRIDGE, Mass., Oct 17, 2024 - (JCN Newswire via SeaPRwire.com) - Eisai Co., Ltd. and Biogen Inc. announced today that the Therapeutic Goods Administration (TGA) of Australia issued a public statement about the initial decision not to register the humanized anti-solubleaggregated amyloid-beta (Aβ) monoclonal antibody lecanemab for the treatment of patients with mild cognitive impairment (MCI)due to Alzheimer’s disease (AD) and mild AD dementia.Eisai will request a reconsideration of this decision under Section 60* of the Therapeutic Goods Act within 90 days to make lecanemab available for eligible people living with early AD in Australia. Following Eisai’s request for review, the TGA will issue a final decision within 60 days of receiving Eisai’s request.Lecanemab is already approved in the United States, Japan, China, South Korea, Hong Kong, Israel UAE and Great Britain, and is being marketed in the U.S., Japan and China.Eisai serves as the lead for lecanemab’s development and regulatory submissions globally with both Eisai and Biogen co-commercializing and co-promoting the product and Eisai having final decision- making authority.*When we receive the outcome of the evaluation, Section 60 of the Australian legislation defines this as an “initial decision”. This is because the legislation states any decision considered an “initial decision” can be reviewed on request. This legislated process is referred to as a“request for a review of an initial decision” by the TGA. Note the specific part of the legislation that defines this is Section 60 of the Therapeutic Goods Act.About lecanemab (Leqembi®)Lecanemab is the result of a strategic research alliance between Eisai and BioArctic. It is a humanized immunoglobulin gamma1 (IgG1) monoclonal antibody directed against aggregated soluble (protofibril) and insoluble forms of amyloid-beta (Aβ).Lecanemab is approved in the U.S., Japan, China, South Korea, Hong Kong, Israel, UAE and Great Britain for the treatment of MCI due to AD and mild AD dementia. Lecanemab’s approvals in these countries were primarily based on Phase 3 data from Eisai’s global Clarity AD clinical trial, in which it met its primary endpoint and all key secondary endpoints with statisticallysignificant results. The most common adverse events (>10%) in the lecanemab group were infusion reactions, ARIA-H (combined cerebral microhemorrhages, cerebral macrohemorrhages, and superficial siderosis), ARIA-E (edema/effusion), headache, and fall.Lecanemab is marketed in the U.S., Japan and China. Eisai has also submitted applications for approval of lecanemab in 10 countries and regions, including the European Union.Since July 2020 the Phase 3 clinical study (AHEAD 3-45) for individuals with preclinical AD, meaning they are clinically normaland have intermediate or elevated levels of amyloid in their brains, is ongoing. AHEAD 3-45 is conducted as a public-private partnership between the Alzheimer's Clinical Trial Consortium that provides the infrastructure for academic clinical trials in AD and related dementias in the U.S, funded by the National Institute on Aging, part of the National Institutes of Health, Eisai and Biogen. Since January 2022, the Tau NexGen clinical study for Dominantly Inherited AD (DIAD), that is conducted by Dominantly Inherited Alzheimer Network Trials Unit (DIAN-TU), led by Washington University School of Medicine in St. Louis, is ongoing and includes lecanemab as the backbone anti- amyloid therapy.About the Collaboration between Eisai and Biogen for ADEisai and Biogen have been collaborating on the joint development and commercialization of AD treatments since 2014. Eisaiserves as the lead of lecanemab development and regulatory submissions globally with both companies co-commercializing and co-promoting the product and Eisai having final decision-making authority.About the Collaboration between Eisai and BioArctic for ADSince 2005, Eisai and BioArctic have had a long-term collaboration regarding the development and commercialization of AD treatments. Eisai obtained the global rights to study, develop, manufacture and market lecanemab for the treatment of AD pursuant to an agreement with BioArctic in December 2007. The development and commercialization agreement on theantibody back-up was signed in May 2015.About Eisai Co., Ltd.Eisai's Corporate Concept is "to give first thought to patients and people in the daily living domain, and to increase the benefits that health care provides." Under this Concept (also known as human health care (hhc) Concept), we aim to effectively achieve social good in the form of relieving anxiety over health and reducing health disparities. With a global network of R&D facilities,manufacturing sites and marketing subsidiaries, we strive to create and deliver innovative products to target diseases with high unmet medical needs, with a particular focus in our strategic areas of Neurology and Oncology.In addition, we demonstrate our commitment to the elimination of neglected tropical diseases (NTDs), which is a target (3.3) of the United Nations Sustainable Development Goals (SDGs), by working on various activities together with global partners.For more information about Eisai, please visit www.eisai.com (for global headquarters: Eisai Co., Ltd.), and connect with us on X, LinkedIn and Facebook. The website and social media channels are intendedfor audiences outside of the UK and Europe. For audiences based in the UK and Europe, please visit www.eisai.eu and Eisai EMEA LinkedIn.About BiogenFounded in 1978, Biogen is a leading biotechnology company that pioneers innovative science to deliver new medicines to transform patient’s lives and to create value for shareholders and our communities. We apply deep understanding of human biology and leverage different modalities to advance first-in-class treatments or therapies that deliver superior outcomes. Our approach is to take bold risks, balanced with return on investment to deliver long-term growth.The company routinely posts information that may be important to investors on its website at www.biogen.com.Follow Biogen on social media – Facebook, LinkedIn, X, YouTube.ContactsMEDIA CONTACT:Eisai Co., Ltd.Public Relations Department+81-(0)3-3817-5120Eisai Europe, Ltd.EMEA Communications Department+44 (0) 7974-879-419Emea-comms@eisai.netEisai Inc. (U.S.) Libby Holman+ 1-201-753-1945Libby_Holman@eisai.comMEDIA CONTACT:Biogen Inc. Jack Cox+ 1-781-464-3260public.affairs@biogen.comINVESTOR CONTACT:Biogen Inc. Stephen Amato+ 1-781-464-2442IR@biogen.comINVESTOR CONTACT:Eisai Co., Ltd.Investor Relations Department+81-(0)70-8688-9685Biogen Safe HarborThis news release contains forward-looking statements, about the potential clinical effects of lecanemab; the potential benefits, safety and efficacy of lecanemab; potential regulatory discussions, submissions and approvals and the timing thereof; thetreatment of Alzheimer's disease; the anticipated benefits and potential of Biogen's collaboration arrangements with Eisai; the potential of Biogen's commercial business and pipeline programs; including lecanemab; and risks and uncertainties associated with drug development and commercialization. These statements may be identified by words such as "aim," "anticipate," "believe," "could," "estimate," "expect," "forecast," "intend," "may," "plan," "possible," "potential," "will," "would" and other words and terms of similar meaning. Drug development and commercialization involve a high degree of risk, and only a small numberof research and development programs result in commercialization of a product. Results in early-stage clinical studies may notbe indicative of full results or results from later stage or larger scale clinical studies and do not ensure regulatory approval. You should not place undue reliance on these statements.These statements involve risks and uncertainties that could cause actual results to differ materially from those reflected in such statements, including without limitation unexpected concerns that may arise from additional data, analysis or results obtained during clinical studies; the occurrence of adverse safety events; risks of unexpected costs or delays; the risk of other unexpected hurdles; regulatory submissions may take longer or be more difficult to complete than expected; regulatoryauthorities may require additional information or further studies, or may fail or refuse to approve or may delay approval of Biogen's drug candidates; including lecanemab; actual timing and content of submissions to and decisions made by the regulatory authorities regarding lecanemab; uncertainty of success in the development and potential commercialization of the medicine; failure to protect and enforce Biogen's data, intellectual property and other proprietary rights and uncertaintiesrelating to intellectual property claims and challenges; product liability claims; and third party collaboration risks, results ofoperations and financial condition. The foregoing sets forth many, but not all, of the factors that could cause actual results todiffer from Biogen's expectations in any forward-looking statement. Investors should consider this cautionary statement as wellas the risk factors identified in Biogen's most recent annual or quarterly report and in other reports Biogen has filed with the U.S.Securities and Exchange Commission. These statements speak only as of the date of this news release. Biogen does notundertake any obligation to publicly update any forward-looking statements. Copyright 2024 JCN Newswire via SeaPRwire.com.

17 10 月, 2024

Regarding the transfer of sales functions related to NEC-brand PCs for commercial customers

NEC Corporation (NEC; TSE: 6701) and NEC Personal Computers, Ltd. (NECPC) today announced an agreement to transfer the sales functions related to NEC-brand PCs for commercial customers from NEC to NECPC. The transfer is scheduled to be completed by the end of March 2025. Once the transfer is complete, NECPC will be responsible for the development, design, manufacturing, marketing and sales of both NEC-brand PCs for consumer and commercial customers.NEC brand PCs for commercial customers are provided to enterprises, organizations and educational institutions under product names such as "VersaPro" and “Mate", and have a reputation as reliable products that support businesses and society. By integrating the management resources of NEC and NECPC, NECPC will develop more competitive products that meet the needs of its customers. In addition, NECPC will enhance the total value of its products by enabling its dedicated PC sales team to work with sales partners to provide faster customer care. Furthermore, NECPC will support the success of its customers by prioritizing the resolution of their challenges and through continuous innovation.“I am confident that this transfer of functions will strengthen the competitiveness and product appeal of NEC-brand PCs for corporate customers. We will also support our customers' workstyle transformation and DX promotion by combining NEC's value creation model, NEC BluStellar, with PCs," said Tetsuhiko Kimura, Corporate Executive Vice President, NEC Corporation.“Since being launched as a joint venture between NEC and Lenovo in 2011, NECPC has always focused on solving the challenges of our customers and society, and has worked on product innovation. By building a system that covers everything from development to sales, I am confident that NECPC will be able to contribute to the success of our customers even more," said Taro Hiyama, President, NEC Personal Computers.About NEC CorporationNEC Corporation has established itself as a leader in the integration of IT and network technologies while promoting the brand statement of “Orchestrating a brighter world.” NEC enables businesses and communities to adapt to rapid changes taking place in both society and the market as it provides for the social values of safety, security, fairness and efficiency to promote a more sustainable world where everyone has the chance to reach their full potential. For more information, visit NEC at https://www.nec.com.  Copyright 2024 JCN Newswire via SeaPRwire.com.

17 10 月, 2024

TANAKA Announces “TK-SK” Palladium Alloy for Semiconductor Test Equipment

TOKYO, Oct 17, 2024 - (JCN Newswire via SeaPRwire.com) - TANAKA Kikinzoku Kogyo K.K. (Head office: Chuo-ku, Tokyo; Representative Director & CEO: Koichiro Tanaka), which develops industrial precious metal products as one of the core companies of TANAKA Precious Metals, has announced the development of TK-SK, a palladium alloy designed for probe pins used in the final testing stage (post-processing) of semiconductor packages. This new product will be showcased via a panel display at SWTest Asia 2024, an exhibition scheduled for October 24–25, 2024, in Fukuoka Prefecture, Japan, with samples available for shipping before the end of the year.Key Features of “TK-SK”:640HV Hardness: This palladium alloy offers maximum hardness of 640HV, making it ideal for use in test socket applications, particularly in the final continuity testing stage (back-end process).TANAKA Kikinzoku Kogyo has manufactured and supplied a range of precious metals for probe pins used in testing equipment in the front-end and back-end processes of semiconductor manufacturing.As a palladium alloy for probe pins, TK-SK exhibits maximum hardness of 640HV that makes it suitable for use in test socket applications mainly in the final continuity testing stage (back-end process).Demand for high-hardness probe pins has increased in recent years. However, one common challenge with harder materials is that they can be more difficult to process and are prone to breaking during machining. Additionally, palladium alloys on the market previously had a maximum hardness of around 560HV. Through its unique processing technology, TANAKA Kikinzoku Kogyo has successfully developed TK-SK with a hardness of 640HV. By 2028, the company aims to ship 1.5 times the volume of its existing products.Pogo pin-type probe pins are typically used in test sockets. During testing, the tip or plunger of the probe pin can become deformed due to friction from contact with substrates. Solder may also adhere to the plungers, needing regular cleaning, which further increases the risk of deformation due to friction. High-hardness probe pins, like TK-SK, reduce wear-related deformation, leading to longer service life and lower maintenance costs for semiconductor test equipment.Looking ahead, TANAKA Kikinzoku Kogyo plans to continue contributing to the development of the semiconductor market, which is expected to experience significant growth in the coming years.TK-SK Properties (Reference Values)Exhibition detailsExhibition name: SWTest Asia 2024Dates: October 24 (10:00–15:30) and October 25 (10:00–16:00), 2024Venue: Hilton Fukuoka Sea Hawk, JapanOfficial website: https://www.swtestasia.org/Exhibitor: TANAKA Kikinzoku Kogyo K.K.Booth No.: 210Panel display: Palladium alloy for probe pins (TK-SK wire, TK-FS wire and sheet), copper-silver alloy for probe pins (TK-101 sheet), and precious metal plating solution for probe cardsAbout TANAKA Precious MetalsSince its foundation in 1885, TANAKA Precious Metals has built a portfolio of products to support a diversified range of business uses focused on precious metals. TANAKA is a leader in Japan regarding the volume of precious metals it handles. Over many years, TANAKA has manufactured and sold precious metal products for industry and provided precious metals in such forms as jewelry and assets. As precious metals specialists, all Group companies in Japan and worldwide collaborate on manufacturing, sales, and technology development to offer a full range of products and services. With 5,355 employees, the group’s consolidated net sales for the fiscal year ending December 2023, was 611.1 billion yen.Global industrial business websitehttps://tanaka-preciousmetals.com/en/Product inquiriesTANAKA Kikinzoku Kogyo K.K.https://tanaka-preciousmetals.com/en/inquiries-on-industrial-products/Press inquiriesTANAKA Holdings Co., Ltd.https://tanaka-preciousmetals.com/en/inquiries-for-media/Press Release: https://www.acnnewswire.com/docs/files/20241017_EN.pdf  Copyright 2024 JCN Newswire via SeaPRwire.com.

17 10 月, 2024

田中贵金属工业发布半导体检查装置用钯合金材料“TK-SK”

东京, 2024年10月17日 - (亚太商讯 via SeaPRwire.com) - 开展工业用贵金属业务的田中贵金属集团核心企业——田中贵金属工业株式会社(总公司:东京都中央区、执行总裁:田中 浩一朗)发布用于半导体封装后段工序最终测试中的探针用钯(Pd)合金材料“TK-SK”。本产品将于2024年10月24日至25日在福冈县举行的“SWTest Asia 2024”展会上进行展板展示,并计划在年内提供样品。田中贵金属工业制造和提供在半导体制造前段及后段工序中检查装置用的各种贵金属探针材料。此次发布的“TK-SK”作为探针用钯合金材料,最大硬度为640HV,因此预计主要用于后段工序最终测试中通电测试的插座。近年来,虽然对更高硬度探针的需求日益增加,但存在着一旦提高硬度,切削时更易损坏等材料加工变难的课题,而且市场上流通的钯合金类材料最大硬度约为560HV。此次,田中贵金属工业利用自有的加工技术,成功开发了硬度到达640HV的“TK-SK”。对于本产品,我们的目标是在2028年前出货量达到现有产品的1.5倍。在测试用插座中,探针使用的是弹簧顶针式(POGO PIN型)探针。在检查过程中,探针的尖端(针头)会因为与基板接触时产生的摩擦而磨损变形。此外,如果针头上粘附了焊料,为了清洁需要刮掉焊料,此时针头也会因磨损而变形。由于检查时发生的变形,检查装置的探针需要定期维护,但通过采用更高硬度的探针,可以减少半导体检查装置中探针磨损带来的变形,有助于延长检查装置的使用寿命和降低成本。田中贵金属工业的目标是今后也为预期不断扩大的半导体市场发展做出贡献。“TK-SK”产品性质参考值展会参展详情展会名称:SWTest Asia 2024展期:2024年10月24日10:00~15:30、10月25日10:00~16:00展会场地:福冈海鹰希尔顿酒店(福冈县福冈市)官网:https://www.swtestasia.org/参展公司:田中贵金属工业株式会社展位编号:210展板展示内容:探针用钯合金材料“TK-SK(线)、TK-FS(线、板)”、探针用铜银合金材料“TK-101(板)”、探针卡用贵金属电镀液关于田中贵金属集团田中贵金属集团自1885 年(明治18年)创业以来,营业范围以贵金属为中心,并以此展开广泛活动。公司在日本国内拥有非常可观的贵金属交易量, 长年以来不遗余力地进行工业用贵金属制品的制造和销售,以及提供作为宝石饰品及资产的贵金属商品。并且,作为贵金属相关的专家集团,日本国内外的各集团公司进行制造、销售以及技术一体化,携手合作提供产品及服务。2023年度(截至2023年12月)集团总营业额为6,111亿日元,拥有5,355名员工。产业事业全球网站https://www.tanaka.com.cn产品咨询表田中贵金属工业株式会社https://www.tanaka.com.cn/inquiries-on-industrial-products/新闻媒体咨询处田中控股株式会社https://www.tanaka.com.cn/inquiries-for-media/新闻稿: https://www.acnnewswire.com/docs/files/20241017_CH.pdf  Copyright 2024 亚太商讯 via SeaPRwire.com.

17 10 月, 2024

Athos宣布其人工智能生成的全新口服G9A抑制剂ATH-063的I期临床试验顶线数据,显示其对强效抗炎调节性T细胞的选择性扩增和激活

ATH-063在所有剂量水平下显著增加了循环调节性T细胞(Tregs)的数量,并在六个与诱导Treg抗炎活性相关的已知基因中表现出富集在任何剂量水平下,未观察到严重不良反应或剂量限制性毒性,且ATH-063表现出良好的药代动力学(PK)这些数据为Athos专有的AI2(用于自身免疫药物开发的人工智能)计算软件平台生成的ATH-063提供了临床验证洛杉矶, 2024年10月17日 - (亚太商讯 via SeaPRwire.com) - Athos Therapeutics, Inc.(“Athos”),一家处于临床阶段的生物技术公司,致力于为免疫介导疾病患者开发精准的小分子疗法,今天宣布了公司I期临床试验的顶线结果。该试验涉及ATH-063,这是一种正在开发中的口服小分子G9A抑制剂,也是公司为治疗炎症性肠病(IBD)开发的主要资产。该临床试验是一项在健康志愿者中进行的随机、双盲、安慰剂对照研究,旨在评估其安全性和药代动力学(PK),并提供药效动力学(PD)数据,以确认ATH-063的拟议作用机制。试验采用了顺序的单剂量递增(SAD,n=32)和多剂量递增(MAD,n=32)组,并设有一个单独的食物效应(FE,n=12)组。ATH-063以四种剂量(25、75、150和250毫克)口服给药。药效动力学(PD)数据表明,ATH-063对调节性T细胞(Tregs)的选择性扩增和激活与Athos AI2平台的预测一致:与安慰剂组相比,所有ATH-063剂量水平下的血液调节性T细胞(Tregs)数量均显著增加(p<0.001),并显示出ATH-063血液浓度与Tregs数量之间的相关性。ATH-063血液浓度与多个调节性T细胞(Tregs)活性关键生物标志物的增加呈正相关,其中与FOXP3的相关性较强(p=0.003)。诱导的调节性T细胞(Tregs)在六个与Treg抗炎活性相关的已知基因中表现出富集。STAT5A,这一与诱导调节性T细胞(Tregs)相关的关键信号分子,在所有队列和剂量中均被激活(p=0.0003)。药效动力学(PD)数据表明与炎症性肠病(IBD)疾病活动性关键生物标志物的相关性,支持进一步开发ATH-063作为IBD的治疗药物ATH-063血液浓度与OSM的减少呈相关性(p=0.012),OSM是与TNFA耐药相关的一个已知生物标志物ATH-063血液浓度与钙卫蛋白单体的减少呈相关性,钙卫蛋白是炎症性肠病(IBD)的一个已知生物标志物ATH-063在所有剂量组中均具有良好的耐受性:在任何剂量水平下,未观察到严重不良反应或剂量限制性毒性。 强劲的药代动力学(PK)结果和剂量成比例的血液水平增加:ATH-063在整个研究过程中显示出良好的药代动力学结果,血液中ATH-063浓度随剂量成比例增加。“我们的ATH-063首次人体临床试验结果超出了我们的高度预期,”Athos创始人、总裁兼首席执行官Dimitrios Iliopoulos博士(PhD,MBA)表示。“我们利用Athos AI2药物开发平台,识别了一个之前未被发现的全新治疗靶点,创造了ATH-063,并在临床前预测了该化合物的拟定作用机制。我们很高兴这些I期结果为Athos AI2计算引擎所做的预测提供了临床验证,”Iliopoulos博士补充道。“我们的I期数据表明,ATH-063每日口服给药具有良好的耐受性,并表现出调节性T细胞(Tregs)的扩增,”Athos创始人兼首席医学官Allan Pantuck博士(MD,MS,FACS)评论道。“我们很高兴进入下一阶段的临床开发,针对中度至重度活动性溃疡性结肠炎患者。ATH-063项目从最初的靶点识别到完成I期临床试验的快速进展,得益于我们利用人工智能进行药物开发的创新方法。”关于ATH-063ATH-063是一种新型的、正在研究中的、由人工智能生成的口服小分子G9A抑制剂,正在开发用于治疗炎症性肠病(IBD)和其他自身免疫性疾病。G9A是一个基因网络的核心节点,该基因网络通过Athos的AI2平台整合Athos IBD生物库的多组学和纵向临床数据被识别出来。ATH-063旨在通过扩增和激活调节性T细胞,直接靶向人类CD4 T细胞和胃肠道上皮细胞中的G9A酶活性,既抑制促炎反应,又通过调节紧密连接蛋白诱导直接的粘膜愈合。关于Athos Therapeutics Athos Therapeutics是一家处于临床阶段的生物技术公司,致力于开发可能成为首创的疗法,从而显著改善自身免疫性疾病和慢性炎症性疾病患者的生活。Athos的药物开发平台始于从全球顶级医院系统获取的超过25,000个高质量患者样本。Athos的AI2平台通过整合多组学和纵向临床数据集来识别新的药物靶点,并将其与小分子计算化学平台相匹配。AI2平台包括Athos的数据湖、已建立的独特组学工作流程以及整合的深度机器学习引擎。公司的主要药物化合物是ATH-063,一种用于治疗炎症性肠病的口服小分子G9A抑制剂。此外,Athos还在开发一系列针对各种自身免疫性疾病的小分子疗法。 关于Athos Therapeutics的更多信息,请访问 https://athostx.com/联系方式:Athos Therapeutics, Inc.Keith Hoffman, PhD, Chief Business Officerkhoffman@athostx.com资料来源:Athos Therapeutics, Inc. Copyright 2024 亚太商讯 via SeaPRwire.com.

17 10 月, 2024

香港董事学会的《施政报告》回应

香港, 2024年10月16日 - (亚太商讯 via SeaPRwire.com) - 香港董事学会就2024年10月16日发表之《施政报告》作出回应。行政长官李家超先生今日发表任内第三份施政报告,篇幅颇长,主要在于深化推进既有长远发展策略及相关措施。然而,长远发展收效需时。故此,施政报告有不少短中期措施扶稳经济。中长期发展本港长远发展,重中之重,是努力发展成为国际创新科技中心,以新质生产力体现高质量经济发展。其中,政府将制订新型工业中长期发展方案,推动成立新型工业发展联盟,促进"政、产、学、研、投"紧密合作,完善新型工业发展策略和体制。另方面,施政报告提到,政府将扩大研究配对资助,加大创科产业投资,成立100亿元"创科产业引导基金",优化"创科创投基金",推出"创科加速器先导计划",应有助创科及新型工业发展。短中期措施行政长官已经向中央提出,优化内地居民来港旅游签注的请求,包括恢复"一签多行"个人游签注及增加"一周一行"个人游签注试点城市,争取更多入境旅客。行政长官也提到,将放宽签证门槛,吸引更多东盟地区旅客来港。越多高端旅客愿意来港,不论是商务差旅抑或消闲游玩,都是好事。高端旅客最重体验。若论高端旅客,中东地区应会是一大来源。他们在港是否容易获得符合清真教义及礼拜需要的设施配套,好可能直接影响他们对香港的印象,是否值得再来或推荐更多人来。行政长官提到,发展盛事旅游经济,既要重质亦要重量。事实上, "盛事"标签不能用的太滥,但旅客来港参加真正盛事之时,有其它不同类型的大小活动顺道参加,可以吸引旅客多留一两天。施政报告推出一系列措施支援中小企,包括再推"还息不还本"融资担保安排,及向"BUD专项基金"注资10亿元等。行政长官又提到,金管局正积极考虑就银行资本要求提供弹性,促进银行为中小企提供融资。我们相信,相关措施,可以帮助中小企应对经济转型的融资需要。行政长官又提到,推动数字经济与实体经济融合发展,例如加速发展数字贸易。扩大"数码转型先导计划"的涵盖范围,应该会帮助更多中小企实现数字转型。政府又将成立"促进银发经济工作组",由政务司副司长任组长,循消费、产业、生产力等五方面推出措施,开拓新的产品和服务满足长者需要,并创造商机。至于"释放银色生产动力"的想法,我们赞同。我们认为,本港人口老化问题越见严重,有长者需要合适政策措施得以照顾安老。但应对老龄化的总体政策应以帮助更多长者打破银色天花板为目标,给予年纪渐大但仍有心有力的长者空间和机会充实暮年生活,做他们想做想干的事,不因年龄成为障碍。施政报告有若干措施,巩固国际金融中心地位,例如便利市民跨境金融安排、建立国际黄金交易市场、提升绿色金融生态系统、建立大宗商品交易生态圈等。优化证券市场的措施,包括优化上市审批流程,争取更多企业来港上市。我们认为,除了内地企业,若能吸引更多支持共建一带一路的国家地区的企业来港上市,会是好事。下调烈酒税须顾及公共健康行政长官宣布,局部下调烈酒税,进口价200元以上从价税率减至10%,估计有8成多烈酒的税率不受影响。学会并不同意全面减免烈酒税,但可以同意,今次减税方案或对高价烈酒提供比较公平的竞争环境。有政界人士或以此认为方案聪明,是耶非耶,仍是见仁见智。高价烈酒与低价烈酒,同样有害健康。日前有议员认为,为高价酒提供税惠,可以鼓励店商引入好酒,可以教育市民分辨好酒云云。按此说法,开放足球以外更多运动球类博彩也不会鼓励赌博,反而会教育市民什么是好球。但我们留意到,政府需要不时播放公共宣传广告,劝谕市民不要沉迷赌博,并提供戒赌辅导相关信息。我们期望政府当局预留资源,提前制订措施,应对减烈酒税后可能多了人会喝酒、喝多了酒而产生的公共健康负面影响。取缔劣质㓥房醖酿多时,行政长官今日宣布,将推出住宅楼宇分间单位出租制度,锐意取缔劣质㓥房,而合符最低规格的将成为被认证、受规管的"简朴房"。我们期待政府公布更多细节,而各界也肯定会仔细斟酌最低规格的标准和定义。㓥房的存在,绝不是香港的光荣。改革体育总会管治施政报告同持提出研究设立体育争议解决制度,学会表示支持,学会也乐意配合政府推动体育发展。其中,香港董事学会一直以来都为体育总会及界别内其它机构提供培训及特定的管治谘询服务,于未来也会继续协助为体育总会及相关机构落实新制订的《机构管治守则》,完善管治水平。经济发展去改善民生行政长官于今日下午的记者会,开宗明义,说出要以经济发展去改善民生。学会一直认为,经济持续增长是寻找资源以解决房屋、贫穷、老年社会和环境等民生问题的最可倚仗的伙伴。行政长官上任以来推行不少政策措施解决积累已久的经济、民生问题,我们表示欣赏。然而,实际效果需要时间才能验证,期间更需财政、人力等资源配合。我们期望经济能尽快回复动力,给下一个财政预算案更多资源弹性,更好更快落实行政长官的施政方向。香港董事学会(简称"HKIoD",又以下简称"学会")香港董事学会为香港代表董事共同努力的首要组织,其宗旨是促进企业永续发展职能,为所有公司、其拥有者、持份者、人类以至地球创造持久价值;为达成使命,学会致力于企业管治("企业管治"又称"公司治理")及董事专业行为上的倡导及釐定相关标准。学会于1997年由创会主席郑慕智博士带领下创始,多年来非常荣幸获得香港特别行政区行政长官担任学会赞助人。学会会员来自不同行业及公司类别,并包括执行董事、非执行董事、独立非执行董事。学会以多元文化及国际视野进行会务,举办活动包括董事培训课程、研讨会与论坛、董事立场喉舌、指引设定、公众教育、董事嘉奖系列、上市公司管治水平釐定等。作为"董事学会环球网络"(Global Network of Director Institutes 简称"GNDI")的成员组织,学会投入全球性联手推动优秀企业管治及董事专业行为。学会亦获委派代办"气候管治行动"(Climate Governance Initiative)之香港分部,该行动是与"世界经济论坛"(World Economic Forum)合作的环球网络,积极促进董事们处理气候变化带来的风险与机遇。详情请浏览:http://www.hkiod.com | http://www.gndi.org | https://climate-governance.org/新闻垂询:香港董事学会王俊泳2889 1414/wing.wong@hkiod.com Copyright 2024 亚太商讯 via SeaPRwire.com.

17 10 月, 2024

Mitsubishi Power Completes Construction of 50MW Woody Biomass-fired Power Plant in Hyuga, Miyazaki Prefecture

TOKYO, Oct 16, 2024 - (JCN Newswire via SeaPRwire.com) - Mitsubishi Power, a power solutions brand of Mitsubishi Heavy Industries, Ltd. (MHI), has completed the construction of a 50-megawatt (MW) class woody biomass-fired power plant in the city of Hyuga, in Miyazaki Prefecture, successfully handing over of the facility within the contract period. The Hyuga Biomass Power Plant, developed by a consortium led by MHI as part of a full turnkey solution for engineering, procurement, and construction (EPC), will be operated by Hyuga Biomass Power Co., Ltd., a special purpose company (SPC).Hyuga Biomass Power PlantThe power plant facility comprises a steam turbine, circulating fluidized bed (CFB) boiler, generator, and other equipment that deliver high combustion efficiency for biomass power generation. Improving power generation and fuel efficiency will lead to further reductions in the plant's environmental impact. The SPC that will operate the plant is jointly owned by Osaka Gas Co., Ltd., ITOCHU Corporation, Tokyo Century Corporation, and Tokyo Energy & Systems Inc. Based on the EPC contract, MHI leveraged its experience with numerous power systems to build and supply the main power generating equipment, including the steam turbines, CFB boiler, and other large auxiliary machinery. MHI Group company Mitsubishi Heavy Industries Power Environmental Solutions, Ltd. provided the air quality control systems (AQCS), while Mitsubishi Electric Corporation supplied the generator and electrical components,* and Fujita Corporation handled the civil engineering and construction.Going forward, MHI Group will continue to focus efforts on the further spread of renewable energy power generation systems such as biomass fuel, which makes effective use of resources and is beneficial in reducing environmental loads, contributing to the stable supply of energy and the conservation of the global environment.*The generator and related electrical components were supplied by Mitsubishi Generator Co., Ltd., which was formed on April 1, 2024, through the integration of MHI and Mitsubishi Electric Corporation's power-generator systems businesses. Mitsubishi Electric handled the power receiving and transforming equipment.About MHI GroupMitsubishi Heavy Industries (MHI) Group is one of the world’s leading industrial groups, spanning energy, smart infrastructure, industrial machinery, aerospace and defense. MHI Group combines cutting-edge technology with deep experience to deliver innovative, integrated solutions that help to realize a carbon neutral world, improve the quality of life and ensure a safer world. For more information, please visit www.mhi.com or follow our insights and stories on spectra.mhi.com. Copyright 2024 JCN Newswire via SeaPRwire.com.

16 10 月, 2024

Orders for Gas Turbines through Partner Firm in China Reaches 150 Units

TOKYO, Oct 16, 2024 - (JCN Newswire via SeaPRwire.com) - Mitsubishi Heavy Industries, Ltd. (MHI) held a commemorative ceremony on October 15 to celebrate reaching cumulative orders for 150 gas turbines units through Dongfang Turbine Co., Ltd. (Deyang, Sichuan Province), a subsidiary of Dongfang Electric Corporation, MHI's partner for the gas turbine business in China.Commemorative CeremonyThe ceremony for the 150-unit milestone was attended by Zhang Yanjun, President of Dongfang Electric, with Liu Hui, Chairman of Dongfang Turbine. MHI was represented by Toshiyuki Hashi, Executive Vice President/President and CEO, Energy Systems, Takashi Tozawa, Senior Vice President/Vice President, Energy Systems, and Takashi Kubo, Senior Vice President/Chief Regional Officer, China. Also attending as a special guest was Qin Zhaohui, President of China Huaneng Group Co.,Ltd., Jiangsu Branch, the customer for the 150th unit.Dongfang Turbine is one of three major manufacturers of heavy electrical equipment in China, handling manufacturing and repair services for steam turbines, gas turbines, and auxiliary plant equipment used for power generation. Since 2003, MHI has gradually expanded its licensing of large-scale gas turbines to the company. In 2015, Mitsubishi Power (China) Co., Ltd., the headquarters for MHI's thermal power systems operations in China, opened the Chengdu Branch in Chengdu, Sichuan Province, with the aim of strengthening the collaboration. In addition, MHI and Dongfang Turbine provide localized after-sale services through Mitsubishi Heavy Industries Dongfang Gas Turbine (Guangzhou) Co., Ltd., a joint venture established in 2004 to enable a swift response to local customer needs.Electricity demand continues to rise in China, and the gas turbine market remains robust against the backdrop of increasing demand for replacing aging coal-fired power generation facilities, as well as demand for load-following power sources in line with the expansion of renewable energy. Amid the rising demand in China for high-efficiency gas turbine combined cycle (GTCC) power generation equipment as a means of reducing environmental loads, MHI has steadily accumulated orders for its highly competitive gas turbines, owing to its state-of-the-art and high-efficiency models, and hydrogen co-firing technology. Shipments of gas turbines made in collaboration with Dongfang Turbine reached 100 units in March 2024, and the number of cumulative orders for gas turbines has now reached the 150 unit mark.Going forward, MHI, along with its power solutions brand, Mitsubishi Power, will continue to work in cooperation with Dongfang Electric and Dongfang Turbine for the development of electric power in China, and contribute to the improvement of energy efficiency and the reduction of environmental impacts.About MHI GroupMitsubishi Heavy Industries (MHI) Group is one of the world’s leading industrial groups, spanning energy, smart infrastructure, industrial machinery, aerospace and defense. MHI Group combines cutting-edge technology with deep experience to deliver innovative, integrated solutions that help to realize a carbon neutral world, improve the quality of life and ensure a safer world. For more information, please visit www.mhi.com or follow our insights and stories on spectra.mhi.com. Copyright 2024 JCN Newswire via SeaPRwire.com.

16 10 月, 2024

Amyotrophic Lateral Sclerosis Treatment “Rozebalamin(R) for Injection 25 mg” Receives The Good Design Award 2024 for Light- Proof Vial Packaging

TOKYO, Oct 16, 2024 - (JCN Newswire via SeaPRwire.com) - Eisai Co., Ltd. announced today that amyotrophic lateral sclerosis (ALS) treatment “Rozebalamin® for Injection 25 mg” (mecobalamin) has received the Good Design Award 2024 (by the Japan Institute of Design Promotion) for its light-proof vial packaging.“Rozebalamin for Injection” was approved in Japan on September 24, 2024 as a treatment for amyotrophic lateral sclerosis. Its active ingredient is mecobalamin, which was developed as a freeze-dried formulation which is dissolved into a solvent at the time of administration. Mecobalamin is chemically unstable when exposed to light, therefore requiring a higher level of light-protection than that of the commonly used light- blocking film made by depositing aluminum onto a PET film (aluminium-deposited PET), from the time of distribution/storage until immediately before administration. However, there is also some necessity for visibility, such as the ability to visually confirm the medication inside the vial at the time of use and see the needle tip when extracting the medication with a syringe.For Rozebalamin, packaging was created with a high level of light-protection by applying a black print to aluminium-deposited PET. While the entire vial is covered by the light-blocking packaging, a resealable window to visibility to inspect the solution inside, and the neck of the vial allows that can be peeled back. In addition, perforations were not added to the film with the aim of maintaining the high capacity for light- protection. In doing so, the conflicting issues of increasing light-protection while maintaining visibility were solved, which was also highly evaluated in this selection. This packaging was co-developed with IL Pharma Packaging Co., Ltd. (Headquarters: Aichi), and the award was also presented to both companies.Eisai considers neurology a therapeutic area of focus. As a human healthcare company, Eisai is committed to further addressing the diverse needs of, and increasing the benefits of, patients, their families, and healthcare professionals, by providing high-quality and easy-to-use Rozebalamin as a new treatment option for ALS patients.About Good Design AwardA Japanese design evaluation and promotion mechanism that was first established in 1957 as the Good Design Product Selection System. As a global design award with participation from numerous domestic and international companies and organizations, it is held annually with the aim of improving the quality of life and utilizing design to solve social issues and themes. The "G Mark," which symbolizes the award, is widely recognized as an emblem of excellent design. www.g-mark.org/en.Media Inquiries:Public Relations Department, Eisai Co., Ltd.+81-(0)3-3817-5120 Copyright 2024 JCN Newswire via SeaPRwire.com.

16 10 月, 2024

泛远国际附属中标阿里巴巴国际站华东中心仓业务

香港, 2024年10月16日 - (亚太商讯 via SeaPRwire.com) - 泛远国际控股集团有限公司(上市编号:2516,下称"泛远国际";连同其附属公司,统称"泛远国际"或"本集团")欣然宣布,本集团间接全资附属公司杭州泛远国际物流有限公司("杭州泛远")成功中标阿里巴巴国际站华东中心仓业务。是次中标有助于公司进一步拓展其业务版图,特别是在华东地区的市场影响力。杭州泛远将依托位于义乌的华东中心仓,辐射整个华东地区,为阿里巴巴国际站商家提供仓库操作服务,包括但不限于接收客户包裹、安检、打包、制单、交货核查、合单发货、仓储等服务。此前,本集团已和阿里巴巴国际站启动深圳中心仓业务,即通过泛远智能异常预警系统,前置分析订单资料,主动监控订单在途异常轨迹,结合AI功能高效地提醒客户及时处理异常订单,减少货件的异常比及处理时间,有效提升客户满意度。本次正式中标阿里巴巴国际站华东中心仓业务,足证阿里巴巴国际站对本集团业务实力的认可与肯定。是次合作之华东中心仓(义乌)亦将为更多跨境电商大平台提供物流服务。阿里巴巴国际站是全球领先的B2B电子商务平台,在全球超过200个国家及地区为买家及供应商提供服务。截至2024财年,阿里巴巴国际站拥有4,800多万专业且活跃的全球企业买家,为广泛的中小企业提供商机匹配、线上交易、数字行销、物流履约、售后保障等全链路贸易服务。为促进货物及资金流转速度提升,阿里巴巴国际站依托其业内独有的B2B"半托管"服务,通过负责物流配送并对物流时效进行保障,为全球买卖家减少延误及保障到货,而当中离不开中心仓的支持。杭州泛远为阿里巴巴国际站华东中心仓提供一系列仓库操作服务,中心仓操作通过仓库升级管理、智能组网、售后保障等,集中帮助中小企业解决物流履约的难题,让其半托管服务更标准,到货更有保障,为阿里巴巴国际站业务发展提供强有力的支持,亦符合当前外贸出海大趋势。本集团作为中国知名的跨境电商物流服务商,在仓储管理及智能化技术应用等方面拥有强大实力,附属公司杭州泛远凭借丰富的行业经验以及优质可靠的跨境物流及仓库服务,成功中标阿里巴巴国际站华东中心仓业务,为拥有广阔需求的大平台提供仓库服务,不仅可为本集团带来业务增长的新机遇,更有助于提升整体品牌影响力,为本集团的长期发展和国际化战略奠定坚实基础。泛远国际控股集团有限公司主席、行政总裁兼执行董事王泉先生表示:"我们非常高兴见证本集团附属公司杭州泛远成功中标阿里巴巴国际站华东中心仓业务,充分体现本集团具备为客户提供优质可靠服务的能力,并获得知名跨境电商平台-阿里巴巴国际站的全面认可。作为中国知名的跨境电商物流服务商,杭州泛远在本次合作中充分发挥仓储管理及智能化技术应用的优势,为阿里巴巴国际站数字化履约添砖加瓦,助力中小企业出海。展望未来,本集团将继续秉持开放共赢的发展理念,充分发挥自身优势,矢志不渝地深化与各大平台的战略合作,共同开拓更为广阔的国际市场,助力更多企业顺利出海。"有关泛远国际控股集团有限公司(股份代号:2516.HK)泛远国际控股集团有限公司于2023年12月在香港联交所主板挂牌上市,为中国知名的跨境电子商务物流服务供应商,主要提供端到端跨境配送服务、货运代理服务以及其他物流服务,致力打造稳、快、优的跨境电子商务物流服务体系。本集团作为中国(杭州)跨境电子商务综合试验区首批试点企业,拥有创新的自研物流运输系统,采用直营网点模式,网点遍布中国主要贸易中心,尤其聚焦于长江三角洲及粤港澳大湾区。本集团设有30多个境内网点,1,100多家供应商网路,服务覆盖全球超过220多个国家和地区,向客户提供多项灵活可靠的跨境配送选项及定制化供应链解决方案。有关杭州泛远国际物流有限公司杭州泛远国际物流有限公司为本集团全资附属公司,主营国际海运、国际空运、国际快件代理业务、跨境电子商务供应链及全球物流仓储整体解决方案等服务。公司秉承"以人为本,倾力亲为"的宗旨,致力于打造以涵盖国际货物运输所有业务门类的操作平台为核心的,集仓储、分拨、配送、物流方案解决为一体的,以跨境物流和全球仓储服务为基础的一站式集成物流解决方案供应商。 Copyright 2024 亚太商讯 via SeaPRwire.com.

16 10 月, 2024

Fujitsu to combat fake news in collaboration with leading Japanese organizations

TOKYO, Oct 16, 2024 - (JCN Newswire via SeaPRwire.com) - Fujitsu today announced that it has begun a project to develop a disinformation countermeasure platform alongside a consortium of leading academic and private sector organizations. Fujitsu was selected as a primary operator for this initiative in July 2024 through a public call for proposals by Japan’s New Energy and Industrial Technology Development Organization (“NEDO”) (1). The effort is part of the Key and Advanced Technology R&D through Cross Community Collaboration Program (“K Program”) (2), which was established with the collabor"ation of Japan’s Cabinet Office, the Japanese Ministry of Economy, Trade and Industry (METI), and other related Japanese ministries, to strengthen and drive Japan’s economic security. The consortium, assembled by Fujitsu, includes the National Institute of Informatics (NII), NEC Corporation, Keio Research Institute at SFC, Institute of Science Tokyo (formerly Tokyo Tech), The University of Tokyo, University of Aizu, Nagoya Institute of Technology, and Osaka University.The project aims to develop the world’s first comprehensive disinformation countermeasure platform that can process false information from initial detection to evidence gathering, analysis, and evaluation, with development slated for completion by the end of fiscal year 2025.Vivek Mahajan, Corporate Vice President, CTO, CPO, Fujitsu Limited, comments: “We are excited to be working on this initiative with a top-tier consortium of Japanese academic and private sector organizations that have a proven track record of combating disinformation. In addition to our consortium partners, Fujitsu will collaborate with relevant government agencies and other organizations to develop a robust countermeasure solution and contribute to solving this serious societal challenge.”Figure 1. Consortium member organizationsAs prime operator of this project, Fujitsu will lead the R&D efforts, technology integration, and construction of the overall platform. Leveraging the latest trends in disinformation tactics and technologies, Fujitsu will also create use cases for public and private sector organizations, facilitating the practical application of the research findings.Technology to be developed and consortium roles1. Information analysis by media type and disinformation detection (Responsible parties: NII, NEC)NIILeveraging its track record in the field of fake media detection, NII will develop a technology to detect deepfakes of images, video and audio from social media posts and other content. The technology will identify how the media content has been created and any areas that have been manipulated and assign a confidence score which will be provided as supporting evidence.NECNEC will develop media understanding technology that extracts content including images, video and audio as text and uses it to analyze matches with social media posts and to collect supporting information.2. Evidence/endorsement management (Responsible parties: Keio Research Institute at SFC, Fujitsu, Osaka University)Keio Research Institute at SFC and FujitsuKeio Research Institute at SFC which has a track record in the field of trusted internet architecture and Fujitsu develop technology to integrate evidence collected from the internet, including the analysis results from technology 1 above. This evidence will be structured and stored as an evidence/endorsement graph (3) to verify authenticity and assess impact.Osaka UniversityOsaka University will leverage its expertise in IoT data analysis to develop technology to collect sensor data as a source of evidence. In cases where information for the target area is incomplete, the system will infer evidence based on available data from neighboring areas. This proactive, AI-driven evidence gathering, mimicking human information collection and inference, is a highly advanced initiative.3. Comprehensive authenticity determination (Responsible parties: Fujitsu, Nagoya Institute of Technology)Fujitsu- Fujitsu will develop technology to analyze the consistency of evidence linked to target information using evidence/endorsement graphs from technology 2. This technology enables comprehensive information authenticity analysis, presenting the results and supporting evidence in a user-friendly manner.- Fujitsu will also develop a specialized Japanese LLM for disinformation countermeasures, utilizing its supercomputer (Fugaku) and LLM (Takane) expertise. This specialized LLM will enhance comprehension of news and social media data, improve logical reasoning capabilities, and enable high-speed, high-accuracy inference for authenticity verification while mitigating hallucinations.Nagoya Institute of TechnologyFujitsu will collaborate with Nagoya Institute of Technology to develop a user interface and information provision technology based on cognitive science, considering factors related to human psychology (e.g., continued influence effect). This will help users to accurately judge the truthfulness of information and encourage appropriate actions, including making efforts to avoid the unintentional spread of false information.4. Evaluation of disinformation impact (Responsible parties: Institute of Science Tokyo, The University of Tokyo, Aizu University)Institute of Science Tokyo, The University of Tokyo, and University of Aizu, with their expertise in computational social science related to social media, will develop technology to assess the impact of disinformation. By extending LLMs to build an AI model for disinformation assessment, the three parties will analyze characteristics of disinformation, such as similarity to past disinformation and proliferation speed, focusing on the source, content, and social context of messages from social media data. This will allow for the evaluation of metrics such as proliferation scale and social impact. This development of technology to visualize and quantitatively assess the social impact of disinformation represents a highly advanced endeavor.Figure 2. Diagram of the disinformation countermeasure platformFuture PlansIn fiscal year 2024, the project will focus on analyzing use cases for private companies and public institutions, defining functional requirements, and initiating R&D of individual technologies, with the final system scheduled for development by the end of fiscal year 2025.By developing this platform, Fujitsu and its consortium partners aim to contribute to economic stability in the face of increasing disinformation risk and with NEDO’s support aid in increasing new industry development, international competitiveness, and strengthening Japan’s global position.Comments from partner academic-industrial organizationsProf. Junichi Yamagishi, National Institute of Informatics, comments:“Combating disinformation demands a sophisticated, integrated arsenal of technologies. Leveraging years of cutting-edge research in technology for detecting fake media, we are going to create a robust foundation for a powerful disinformation defense system.”Motoo Nishihara, Corporate Executive Vice President and CTO, NEC Corporation, comments:"We are excited to join this important initiative. As AI is linked to the production of increasingly sophisticated disinformation, AI-powered countermeasures are paramount. Leveraging NEC's cutting-edge AI technologies, we aim to contribute to the development of truly effective solutions."Prof. Hiroyuki Kusumoto, Faculty of Environment and Information Studies, Keio University, and Project Professor Shigeya Suzuki, Graduate School of Media and Governance, Keio University, comment:“Information on the internet nowadays is not only transmitted by individuals, but also by information systems utilizing LLMs. Leveraging cutting-edge digital identity technology, we will create a platform that meticulously tracks sender identity and information relationships, enabling multifaceted analysis for more informed and accurate end-user decision-making.”Prof. Kazutoshi Sasahara, Institute of Science Tokyo, comments:“The increasing scale and sophistication of disinformation pose a grave threat to our daily lives and democracy. With AI making truth increasingly indistinguishable from falsehood, developing technologies to assess the influence of disinformation is a critical, urgent task. We aim to spearhead the development of widely accessible tools to combat this escalating challenge.”Prof. Masashi Toyoda, The University of Tokyo, comments:"We are excited to have the opportunity to collaborate with experts from diverse fields in tackling the challenge of misinformation. We will leverage a wide range of expertise and technologies to build a foundational infrastructure for assessing the impact of disinformation."Yasuhiro Hashimoto, Senior Associate Professor, Aizu University, comments:“The generation and spread of disinformation pose a grave threat to societal stability and national security, demanding a multidisciplinary approach drawing on informatics, engineering, social sciences, and more. We will develop technologies to visualize the large-scale structures and complex relationships in which disinformation circulates, and build an environment where the dynamics of disinformation can be quickly viewed and analyzed.”Prof. Yuko Tanaka, Nagoya Institute of Technology, comments:"I am pleased to participate in this project that integrates cutting-edge technologies to address the increasingly sophisticated and serious circulation of disinformation. I am contributing to the development of interface design that effectively communicates the results—from disinformation detection to evaluation—by considering human cognitive characteristics."Shin’ichi Arakawa, Associate Professor, Osaka University, comments:"We are excited to be involved in R&D that addresses the growing problem of disinformation. Within the project, we will focus on practical research and development, and on delivering real-world impact, going beyond theoretical evaluation."(1) Key and Advanced Technology R&D through Cross Community Collaboration Program Press Release regarding the Key and Advanced Technology R&D through Cross Community Collaboration/Development of Disinformation Analysis Technology (K Program) :www.nedo.go.jp/koubo/CD2_100359.html (in Japanese)[2] Key and Advanced Technology R&D through Cross Community (“K Program”) :www8.cao.go.jp/cstp/anzen_anshin/kprogram.html (in Japanese)[3]Evidence/Endorsement Graph :Information added to the target information that serves as the basis for authenticity judgment, such as the sender (person or organization and its attributes), location, and date.About FujitsuFujitsu’s purpose is to make the world more sustainable by building trust in society through innovation. As the digital transformation partner of choice for customers in over 100 countries, our 124,000 employees work to resolve some of the greatest challenges facing humanity. Our range of services and solutions draw on five key technologies: Computing, Networks, AI, Data & Security, and Converging Technologies, which we bring together to deliver sustainability transformation. Fujitsu Limited (TSE:6702) reported consolidated revenues of 3.7 trillion yen (US$26 billion) for the fiscal year ended March 31, 2024 and remains the top digital services company in Japan by market share. Find out more: www.fujitsu.com.About National Institute of InformaticsNII is Japan's only academic research institute dedicated to the new discipline of informatics. Its mission is to "create future value" in informatics. NII conducts both long-term basic research and practical research aimed at solving social problems in a wide range of informatics research fields, from fundamental theories to the latest topics, such as artificial intelligence, big data, the Internet of Things, and information security.As an inter-university research institute, NII builds and operates academic information infrastructure essential for the research and educational activities of the entire academic community (including the Science Information Network) as well as developing services such as those that enable the provision of academic content and service platforms.https://www.nii.ac.jp/en/.About NEC CorporationNEC Corporation has established itself as a leader in the integration of IT and network technologies while promoting the brand statement of “Orchestrating a brighter world.” NEC enables businesses and communities to adapt to rapid changes taking place in both society and the market as it provides for the social values of safety, security, fairness and efficiency to promote a more sustainable world where everyone has the chance to reach their full potential. For more information, visit NEC at http://www.nec.com.About Keio Research Institute at SFCThe Keio Research Institute at SFC was established in 1996. In its capacity as an academic entity and research institute affiliated with the Graduate School of Media and Governance, Graduate School of Health Management, Faculty of Policy Management, Faculty of Environment and Information Studies, and Faculty of Nursing and Medical Care, the institute serves as a platform for promoting advanced research activities and collaborative initiatives involving the community and local regions. By 2021, the institute had more than 40 laboratories (transdisciplinary research groups with advanced research missions) and more than 30 SFC research consortiums (joint research deployed by the Keio Research Institute at SFC in conjunction with a number of external organizations), and together with approximately 500 senior and guest researchers from various industries, government, and academia, aims to develop unique research to create a vital society. In this manner, the Keio Research Institute at SFC has an impressive wealth of experience and track record in the creation of pioneering knowledge through collaborations among industry, government, and academia.About Institute of Industrial Science, The University of TokyoThe Institute of Industrial Science, The University of Tokyo (UTokyo-IIS) is one of the largest university-attached research institutes in Japan. UTokyo-IIS is comprised of over 120 research laboratories—each headed by a faculty member—and has over 1,200 members (approximately 400 staff and 800 students) actively engaged in education and research. Its activities cover almost all areas of engineering. Since its foundation in 1949, UTokyo-IIS has worked to bridge the huge gaps that exist between academic disciplines and real-world applications.About University of AizuNurtures talent who will exercise leadership in the knowledge-based society.Nurtures computer scientists and highly-skilled computer engineers who will create and exploit "knowledge" for the new era.Has first-class faculty members from almost twenty countries around the world.Provides an outstanding computer environment unparalleled by other universities.Established the graduate school open to the world, where English is used as the common language.Fosters students' latent limitless creativity by training critical thinking and appreciating their curiosity, free from preconceived ideas.About Nagoya Institute of TechnologyNagoya Institute of Technology (NITech) was founded as the first national institution of higher education in central Japan in order to develop the region as Japan’s center of industry. Maintaining a respect for this historic mission and acting as one of the leading engineering institutes in Japan, NITech shall therefore make its fundamental mission as follows: developing revolutionary science and technologies, fostering rich human resources, and contributing to peace and social welfare of the future by acting as a source to consistently produce and develop new industries and culture.About Osaka UniversityOsaka University was founded in 1931 as one of Japan’s imperial universities through strong demand from political and business circles in Osaka, as well as the people of Osaka City and Prefecture. The spiritual roots of Osaka University can be found in Kaitokudo and Tekijuku, educational institutions of the Edo period. After its merger with Osaka University of Foreign Studies in 2007, Osaka University became a comprehensive university with its own School of Foreign Studies. Boasting 11 undergraduate schools, 15 graduate schools, and 6 affiliated research institutes excelling in the fields of the humanities and social sciences, medicine, dentistry, pharmacy, science, and engineering, Osaka University is one of Japan’s premier comprehensive research universities.Osaka University will celebrate the 100th anniversary of its founding in 2031. We will contribute to the creation of a society where each member feels worth living through co-creation with diverse stakeholders to solve local and global challenges in accordance with the university's motto of “Live Locally, Grow Globally.”Press ContactsFujitsu LimitedPublic and Investor Relations DivisionInquiriesNational Institute for Informatics Research Organization of Information and SystemsPublicity Team, Planning Division, General Affairs DepartmentTEL: +81-3-4212-2164E-mail: media@nii.ac.jpNEC Corporate CommunicationsE-mail: press@news.jp.nec.comKeio Research Institute at SFCOffice of Research Development and Sponsored Projects Shonan Fujisawa CampusE-mail: kri-pr@sfc.keio.co.jpThe Institute of Industrial Science, The University of TokyoPublic Relation OfficeE-mail: pro@iis.u-tokyo.ac.jpUniversity of AizuPlanning and Collaboration DivisionPlanning and Public Relations SectionTEL: +81-242-37-2510E-mail: cl-planpr@u-aizu.ac.jpNagoya Institute of TechnologyFoundations GroupProfessor TANAKA YukoE-mail: tanaka.yuko@nitech.ac.jpOsaka UniversityGraduate School of Information Science and TechnologyAssociate Professor Shin’ichi ArakawaE-mail: arakawa@ist.osaka-u.ac.jp Copyright 2024 JCN Newswire via SeaPRwire.com.

16 10 月, 2024

Mitsubishi Heavy Industries Invests in Koloma, a US-Based Geologic Hydrogen Exploration Startup

TOKYO, Oct 16, 2024 - (JCN Newswire via SeaPRwire.com) - Mitsubishi Heavy Industries, Ltd. (MHI) announced that it has invested in Koloma, a startup company headquartered in Denver, Colorado. The investment has been executed through Mitsubishi Heavy Industries America, Inc. (MHIA), which joins a syndicate of investors, including Breakthrough Energy Ventures, Amazon's Climate Pledge Fund, United Airline's Sustainable Flight Fund and Energy Impact Partners.Koloma Natural Hydrogen Exploration SiteKoloma is a geologic hydrogen company that leverages its technology, proprietary data, and human capital advantages to identify and commercialize geologic hydrogen on a global scale. Koloma is actively engaged in exploration and appraisal of assets that will play a significant role in global decarbonization efforts. As the rapidly emerging geologic hydrogen industry takes shape, Koloma's data-driven approach helps power the discovery of geologic hydrogen resources around the world."Building a hydrogen solution ecosystem is one of the core strategies in the energy transition business for MHI," said Takajiro Ishikawa, President and CEO of MHIA. "In MHI's role as a value chain solutions provider, we are aiming to accelerate the hydrogen economy by both offering cutting-edge technologies and enabling breakthrough innovations in the hydrogen space through investments into startups.""We are excited to welcome Mitsubishi Heavy Industries to the Koloma family," said Pete Johnson, CEO of Koloma. "Partnerships with industrial leaders like MHI will maximize the positive impact geologic hydrogen can have as a new clean primary energy source. We look forward to collaborating and innovating together to drive progress in this field and in the broader energy transition."MHI Group is collaborating with and investing in partners to develop innovative technologies that will help to decarbonize existing infrastructures and help build a hydrogen ecosystem to contribute towards achieving a decarbonized society. The Company will continue to enhance and diversify its solutions portfolio to provide customers with alternative decarbonization technologies to achieve their net zero goals.About MHI GroupMitsubishi Heavy Industries (MHI) Group is one of the world’s leading industrial groups, spanning energy, smart infrastructure, industrial machinery, aerospace and defense. MHI Group combines cutting-edge technology with deep experience to deliver innovative, integrated solutions that help to realize a carbon neutral world, improve the quality of life and ensure a safer world. For more information, please visit www.mhi.com or follow our insights and stories on spectra.mhi.com. Copyright 2024 JCN Newswire via SeaPRwire.com.

16 10 月, 2024

Fujitsu implements global launch of world’s first AI application to prevent quality degradation in 5G wireless networks

KAWASAKI, Japan, Oct 15, 2024 - (JCN Newswire via SeaPRwire.com) - Fujitsu today announced the development of an application that leverages AI technology to enhance mobile network communication quality, while achieving energy savings and optimizing network operations. This development is part of the Research and Development Project of the Enhanced Infrastructures for Post-5G Information and Communication Systems (hereafter NEDO-led project) (1) conducted by the New Energy and Industrial Technology Development Organization (NEDO). Fujitsu, which has a successful track record of introducing radio unit (RU) products to the global market, will incorporate this technology into its O-RAN (2) compliant Service Management and Orchestration (SMO) (3) system, FUJITSU Network Virtuora Service Management and Orchestration. Fujitsu will implement a gradual global rollout of the technology to mobile network operators starting in November 2024 by leveraging the footprint it has already cultivated in RU.This application comprises three key technologies:An AI-powered technology that can estimate smartphone users’ quality of experience (QoE) on their networks in real time.A technology that detects early signs of increased communication traffic and proactively prevents network quality degradation.A technology that detects network quality degradation and redefines the area covered by peripheral base stations to maintain optimal quality.Fujitsu verified the effectiveness of these technologies in August 2024 using real commercial data from mobile network operators (4) under conditions closely resembling actual operating environments.This application will ensure a seamless and reliable connection for mobile network users, not only during normal operations but also during emergencies and periods of increased network traffic, ultimately enhancing user convenience, satisfaction, and safety in critical situations. For mobile network operators, the application will reduce operational costs and save power through optimized operations.BackgroundAs digital transformation (DX) accelerates globally, the adoption of 5G mobile networks is rapidly expanding as a key infrastructure component. Mobile network operators are expected to further enhance their capabilities, including ultra-low latency and simultaneous connectivity, while ensuring network quality at user and application levels. Furthermore, the RAN (Radio Access Network) domain is undergoing open and virtualized transformation based on the O-RAN concept, leading to anticipated reductions in total cost of ownership (TCO).The three technologies in this application operate on the RIC (5) deployed within the O-RAN compliant SMO, contributing to the intelligent automation and self-sufficiency of RAN.Development achievements1. Real-time QoE estimation and quality assurance using AIThis technology estimates QoE in real-time and automatically switches users to other base station network areas when QoE degradation is detected. It is a world-first, enabling the creation of AI models that can easily estimate QoE for individual applications by selecting feature values from statistical data (KPIs) calculated from high-speed packet analysis for 100 Gbps RAN traffic. This approach allows for flexible adaptation to various applications.By accurately understanding the QoE of each user and assigning the necessary resources, this technology ensures user convenience and satisfaction while simultaneously suppressing excessive resource allocation. This results in a 19% increase in the number of users that can be accommodated per base station (6).Figure 1: QoE estimation based on packet analysis2. Proactive base station activation/deactivation for quality maintenance and energy savingsFujitsu has developed a technology that utilizes AI to anticipate increased communication traffic and proactively activate previously dormant base stations to prevent degradation in user communication quality.Previously, energy savings were achieved by monitoring traffic in each area in real-time and putting unnecessary base stations into sleep mode. This world first technology goes a step further by detecting unusual increases in pedestrian traffic, such as those associated with local events, and predicting subsequent traffic increases at the grid level (7). This predictive technology has been proven to successfully activate base stations in advance without impacting user quality 99.8% of the time during the verification period.This enables pinpoint activation and deactivation of base stations based on traffic conditions, achieving a balance between maintaining QoE and saving energy when combined with the energy-saving application announced by Fujitsu in December 2023 (8).3. Detection of service quality degradation and area redesign for service quality maintenanceTraditional anomaly detection technologies for single cells (9) struggled to differentiate between simple load reductions and actual anomalies. Fujitsu's new technology addresses this by comparing traffic trends across surrounding cells using AI, achieving a fault detection accuracy rate of over 92%. This technology supports both supervised learning with limited fault data as well as unsupervised learning. By understanding the service impact including cell overlap, it is possible to make a judgement on which areas should be recovered first.When this anomaly detection technology identifies areas undergoing significant service impact, it utilizes a radio propagation prediction model that considers path loss (10) in the real field, in addition to the direction and load conditions of surrounding cells, to calculate the optimal tilt angle for surrounding cells. This minimizes the impact on service quality caused by faulty cells. As a result, recovery time from anomalies such as equipment failure, which previously took 24 hours, has been reduced to less than one hour, minimizing the impact on users.Figure 2: Service quality degradation detection and recoveryFuture PlansFujitsu will continue to contribute to the realization of a safer, more secure, and sustainable society by providing O-RAN products using AI-centric technologies for networks that support applications and services across industries.[1] NEDO-led project :Project name: Research and Development Project of the Enhanced Infrastructures for Post-5G Information and Communication Systems (JPNP20017) (Commissioned)Period: FY2021 - 2024Overview: Research and Development Project of the Enhanced Infrastructures for Post-5G Information and Communication Systems[2] O-RAN :O-RAN refers to a Radio Access Network (RAN) built based on open interface specifications developed by the O-RAN ALLIANCE.[3] Service Management and Orchestration (SMO) :In the O-RAN architecture, Service Management and Orchestration (SMO) defines a system that manages the operation, maintenance, and optimization of RAN, as well as its lifecycle.[4] Commercial data from mobile network operators :This refers to data collected by mobile network operators during their actual operations. This data is used in AI development for this research and development project.[5] RIC :Abbreviation for RAN Intelligent Controller, a controller that autonomously executes and controls RAN parameter settings and operational optimization.[6] A 19% increase in the number of users that can be accommodated per base station :This figure was calculated based on a comparison of cell-based performance measurements and QoE-based performance measurements in Fujitsu's lab environment.[7] Grid :A grid refers to a section on a map based on latitude and longitude.[8] The energy-saving application announced by Fujitsu in December 2023 :This refers to an energy-saving application that applies Fujitsu's AI technology to estimate communication traffic based on the distribution of user location information in the mobile network.Press Release: “Fujitsu leverages AI technology to realize energy saving in network operations”[9] Cell :A cell is the smallest unit of a communication area formed by the radio waves of a base station.[10] Path loss :Path loss refers to the attenuation of radio waves as they pass through the air or are blocked by obstacles.About FujitsuFujitsu’s purpose is to make the world more sustainable by building trust in society through innovation. As the digital transformation partner of choice for customers in over 100 countries, our 124,000 employees work to resolve some of the greatest challenges facing humanity. Our range of services and solutions draw on five key technologies: Computing, Networks, AI, Data & Security, and Converging Technologies, which we bring together to deliver sustainability transformation. Fujitsu Limited (TSE:6702) reported consolidated revenues of 3.7 trillion yen (US$26 billion) for the fiscal year ended March 31, 2024 and remains the top digital services company in Japan by market share. Find out more: www.fujitsu.com.Press ContactsFujitsu LimitedPublic and Investor Relations DivisionInquiries Copyright 2024 JCN Newswire via SeaPRwire.com.

15 10 月, 2024